T cells activity is promoted with antigen specific cytotoxic activity as well as the activity of B cells which produce antibodies.
During sleep the stress producing HPA axis and sympathetic nervous system is decreased as well as the production of cortisol, epinephrine and norepinephrine. Growth hormone and melatonin increase. There are some proinflammatory signals that help support immune cell function.
Sleep deprivation causes profound stress that results in detrimental changes in health and immune function. There is increased inflammatory activity with elevated Il-6 and TNF alpha. Low grade systemic inflammation fuels type 2 diabetes and cardiovascular disease.
Chronic sleep loss leads to immunodeficiency.
The purpose of sleep is fatigue reversal, biochemical refreshment with synaptoblastic activity, memory enhancement and immune system support with better mental health.
It is crucial now to get your 8-9 hours of sleep. Your life could depend on it.
Michael Gelb DDS, MS